Endocrine Abstracts

The role of systemic inflammation in promoting tumor progression has been a topic of increasing interest. Neutrophil-lymphocyte ratio (NLR) >5 and platelet-lymphocyte ratio (PLR) >190 used as indicators of inflammation have been reported to have prognostic value in numerous solid tumors. The aim of this retrospective study was to investigate NLR and PLR as biomarkers in distinguishing between adrenocortical adenomas and adrenocortical carcinomas (ACC). Nineteen patient...

Introduction: Cushing’s disease (CD) is an uncommon condition of excess endogenous glucocorticoids caused by ACTH secreting pituitary corticotroph adenoma. The purpose of this study is to review therapeutic outcomes and comorbidity of patients with CD in a single centre.Methods: We conducted a retrospective study of 33 patients with CD undergoing transsphenoidal surgery from January 2007 to February 2014. (27 female and six male, median age 38 years...

Empty sella is characterized by the radiological appearance of an enlarged or deformed sella turcica which is completely or partially filled with cerebrospinal fluid resulting in a displacement of the normal pituitary gland. Primary empty sella (PES) refers to the empty sella appearance of unknown etiology, diagnosed after excluding a history of previous pituitary pathology. The prevalence of hypopituitarism in empty sella syndrome varies between 2 and 32% in different publish...

Objective: This study aimed to investigate the diagnostic performance of 18F-choline PET/CT in patients with negative or inconclusive results of 99mTc-sestamibi SPECT/CT in locating hyperfunctioning parathyroid tissue in primary hyperparathyroidism patients.Methods: We conducted a retrospective study involving patients who were operated on due to primary hyperparathyroidism from April 2019 to March 2022. The analysis focused on pati...

Background: Systematic or randomised studies on the natural course of non-functioning pituitary macroadenomas after surgery (NFPA) are lacking.Objectives: This study aimed to evaluate the long-term outcomes of residual NFPA following pituitary surgery.Methods: In this retrospective study, we included 130 patients with NPFA who underwent pituitary surgery between 2005 and 2018 at University Hospital Centre Zagreb. The median age of ...

Introduction: Mitotane is widely used to treat adrenocortical carcinoma (ACC) and remains the mainstay of treatment along with surgery. The aim of this study is to evaluate the adverse side effects of mitotane treatment.Materials and Methods: This retrospective study included 36 patients with ACC, ENSAT stage I- IV, who were treated with mitotane in an adjuvant or palliative setting. Patients with ENSAT stage IV who died within 6 months after surgery wer...

Recognizing the site of origin of craniopharyngioma (CP) along the hypothalamus-pituitary axis according to pre-operative MR is helpful to understand its growth pattern in relation to hypothalamus, which is critical in the prediction of hypothalamic injury and planning of treatment. We retrospectively classified 29 CP according to MR pre-operative image study using modified classification of Tang et al. (Nature, 8:10215, 2018). According to its relation to pituitary s...

Background: The aim of this study was to evaluate the outcomes of medical treatment in patients with active acromegaly.Material and Methods: We performed a retrospective analysis of 163 patients (101 female, age at diagnosis 47.2±13.4 years) treated between 1990 and 2020., of which 53 were on medical treatment (32.5%). Remission rate after pituitary surgery was 66.5% (n=105/158; 5 patients refused surgery). Patients who did not achieve remiss...

Purpose: To evaluate the value of early postoperative growth hormone (GH) as a predictor of surgical remission of acromegaly.Methods: We conducted a retrospective search through our database of patients who underwent transsphenoidal surgery for GH-secreting pituitary adenoma from 2011 to June 2022. Only patients who underwent the first pituitary surgery and had GH measurements on the fifth postoperative day were included. The surgical remission was defin...

Background: Laparoscopic adrenalectomy (LA) is the standard treatment for benign adrenal tumours but its role in the surgical management of adrenocortical carcinoma (ACC) is controversial. Therefore, the aim of this study was to compare long-term outcome between open adrenalectomy (OA) and LA in the treatment of primary ACC.Methods: This retrospective cohort study included patients with ACC ENSAT stage I-III referred to the Croatian referral centre for a...